Centromere chromatin structure – Lessons from neocentromeres
نویسندگان
چکیده
منابع مشابه
Neocentromeres
Do neocentromeres lead to disease? Not necessarily. What they do is stabilize chromosome fragments that would have otherwise been lost from daughter cells during cell division. Thus, it could be for some individuals that cells (or embryos) would have died due to chromosome loss if a neocentromere had not formed following inactivation of the natural centromere. Furthermore, centromere inactivati...
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We have taken advantage of the known structural parameters associated with centromere DNA in vivo to construct a CEN fragment that can be selectively excised from the chromatin DNA with restriction endonucleases. CEN3 DNA is organized in chromatin such that a 220-250-bp region encompassing the elements of centromere homology is resistant to nuclease digestion. Restriction enzyme linkers encodin...
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Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Drosophila has at least five different types of insulators; recent results suggest that these different insulators share some components that may allow them to function through common mechanisms. Data from genome-wide localization studies of insulator proteins indicate a possible functional specialization, w...
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A comparative analysis of the conserved region of primate alpha satellite DNA and of a human neocentromere is reported. The two types of centromere DNA share structural features, possibly defining mitotically functional human centromere DNA. These features consist of double dyad symmetries of a particular size, as well as short conserved base motifs adjacent to the dyad symmetries. The possible...
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Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously associated with kinetochore proteins, and they restore chromosome segregation to chromosomes lacking a functional centromere. Neocentromeres have been...
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ژورنال
عنوان ژورنال: Experimental Cell Research
سال: 2020
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2020.111899